Dr. Federico Comoglio

Cambridge Institute for Medical Research (UK)







Professional Preparation


Postdoctoral fellow. University of Cambridge, Cambridge Institute for Medical Research, 2015-2017.


PhD student. ETH Zurich, Department of Biosystems Science and Engineering (D-BSSE), Basel, Switzerland, 2010-2015.


M. Sc. in Medical and Pharmaceutical Biotechnology, University of Piemonte Orientale \Amedeo Avogadro", 2010.


B. Sc. in Biotechnology, University of Piemonte Orientale \Amedeo Avogadro", 2008.



Selected Publications

Ciabrelli F, Comoglio F, Fellous S, Bonev B, Ninova, M, Szabo Q, Xuereb A, Klopp C, Aravin A, Paro R, Bantignies F and Cavalli G  Stable.
Polycomb-dependent transgenerational inheritance of chromatin states in Drosophila. Nature Genetics.


Mohr S*, Dobele C*, Comoglio F* et al.  Hoxa9 and Meis1 cooperatively induce addiction to Syk signaling by suppressing miR-146a in
acute myeloid leukemia. (*equal contribution) Cancer Cell (2017).


Loughran SJ, Comoglio F, Hamey FK, Giustacchini A, Errami Y, Earp E, Gottgens B, Jacobsen SEW, Mead AJ, Hendrich B and Green AR (2017) Mbd3/NuRD controls lymphoid cell fate and inhibits tumorigenesis by repressing a B cell transcriptional program. J. Exp. Med. (2017).


Hauri S*, Comoglio F*, Seimiya M, Gerstung M, Glatter T, Hansen KH, Aebersold R, Paro R, Gstaiger M and Beisel C (2016) A high density map for navigating the human Polycomb complexome. (equal contribution) Cell Reports (2016).


Chiu TP*, Comoglio F*, Zhou T, Yang L, Paro R and Rohs R (2016) DNAshapeR: an R/Bioconductor package for DNA shape prediction
and feature encoding. (equal contribution listed in alphabetic order) Bioinformatics (2016).


Katsuyama T, Comoglio F, Cabuy E, Seimiya M, Oakeley E and Paro R. During Drosophila disc regeneration JAK/STAT coordinates cell proliferation with Ilp8-mediated developmental delay. Proc. Natl. Acad. Sci. U.S.A. (2015).


Comoglio F, Schlumpf T, Schmid V, Rohs R, Beisel C and Paro R. High-Resolution Proling of Drosophila Replication Start Sites Reveals a
DNA Shape and Chromatin Signature of Metazoan Origins. Cell Reports


Comoglio F, Sievers C and Paro R, Sensitive and highly resolved identication of RNA-protein interaction sites in PAR-CLIP data. BMC Bioinformatics (2015).


Comoglio F and Paro R. Combinatorial modeling of chromatin features quantitatively predicts DNA replication timing in Drosophila.
PLoS Comput Biol. (2014).





Google Scholar Profile





Software and resources

Developer/maintainer of

  • the R/BioC packages DNAshapeR (with Chiu T-P) and wavClusteR (with Sievers C)
  • the R packages dupiR and Rknots (with Rinaldi M).
  • the Wolfram Mathematica module HPKnots (with Rinaldi M)